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Papillomavirus and p53

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  • Harald zur Hausen

    (the Deutsches Krebsforschungszentrum)

Abstract

Certain types of human papillomavirus (HPV) are involved in the development of cervical and other perianal cancers, and a new study takes us a step closer to working out how. An HPV-encoded oncoprotein known as E6 can interact with the human tumour suppressor p53, inactivating it and preventing it from carrying out its normal functions. The authors have found that people can carry either an arginine or a proline residue at a specific position in p53, and that E6 binds best to the arginine form. What's more, they've found that people with two copies of the p53 gene that specifies the arginine residue have a seven-fold higher risk of developing cervical cancer than those without.

Suggested Citation

  • Harald zur Hausen, 1998. "Papillomavirus and p53," Nature, Nature, vol. 393(6682), pages 217-217, May.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6682:d:10.1038_30363
    DOI: 10.1038/30363
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