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Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

Author

Listed:
  • Beatriz A. Rocha

    (University of North Texas Health Science Center)

  • Kimberly Scearce-Levie

    (Center for Neurobiology and Behavior, Columbia University)

  • José J. Lucas

    (Center for Neurobiology and Behavior, Columbia University
    Universidad Autonoma Madrid)

  • Noboru Hiroi

    (Laboratory of Molecular Psychiatry, Yale University School of Medicine
    Albert Einstein College of Medicine)

  • Nathalie Castanon

    (Center for Neurobiology and Behavior, Columbia University
    INSERM, Institute Franois Magendic)

  • John C. Crabbe

    (Department of Veterans Affairs Medical Center and Oregon Health Sciences University)

  • Eric J. Nestler

    (Laboratory of Molecular Psychiatry, Yale University School of Medicine)

  • René Hen

    (Center for Neurobiology and Behavior, Columbia University)

Abstract

There is increasing evidence that genetic factors can influence individual differences in vulnerability to drugs of abuse1,2. Serotonin (5-hydroxytryptamine, 5-HT), acting through many receptors can modulate the activity of neural reward pathways and thus the effects of various drugs of abuse3,4,5,6,7,8. Here we examine the effects of cocaine in mice lacking one of the serotonin-receptor subtypes, the 5-HT1B receptor9. We show that mice lacking 5-HT1B display increased locomotor responses to cocaine and that they are more motivated to self-administer cocaine. We propose that even drug-naive 5-HT1B-knockout mice are in a behavioural and biochemical state that resembles that of wild-type mice sensitized to cocaine by repeated exposure to the drug. This altered state might be responsible for their increased vulnerability to cocaine.

Suggested Citation

  • Beatriz A. Rocha & Kimberly Scearce-Levie & José J. Lucas & Noboru Hiroi & Nathalie Castanon & John C. Crabbe & Eric J. Nestler & René Hen, 1998. "Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor," Nature, Nature, vol. 393(6681), pages 175-178, May.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6681:d:10.1038_30259
    DOI: 10.1038/30259
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    1. Koc, Erdogan & Boz, Hakan, 2014. "Psychoneurobiochemistry of tourism marketing," Tourism Management, Elsevier, vol. 44(C), pages 140-148.

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