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Imprinted gene in postnatal growth role

Author

Listed:
  • Jean-Michel Itier

    (Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville)

  • Günter L. Tremp

    (Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville)

  • Jean-François Léonard

    (Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville)

  • Marie-Christine Multon

    (Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville)

  • Gwénaëlle Ret

    (Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville)

  • Fabien Schweighoffer

    (BioScreen Therapeutics)

  • Bruno Tocqué

    (BioScreen Therapeutics)

  • Marie-Thérèse Bluet-Pajot

    (Biodynamique des Systémes Neuroendocriniens, INSERM U-159)

  • Valérie Cormier

    (Unité de Recherches sur les Handicaps Génétiques de l Enfant, INSERM U-393)

  • François Dautry

    (Génétique Moléculaire et Intégration des Fonctions Cellulaires, CNRS UPR 9044, Institut de Recherches sur le Cancer)

Abstract

Mice that have been specially bred to lack a protein known as Grf-1, which is normally found only in the brain, do not grow properly after they are born and remain small all their lives. We have now identified a function of Grf-1 as an important regulator of the synthesis and release of growth hormone. Moreover, grf1, the gene encoding this protein, is unlike other imprinted genes that affect growth because it operates after, rather than before, birth.

Suggested Citation

  • Jean-Michel Itier & Günter L. Tremp & Jean-François Léonard & Marie-Christine Multon & Gwénaëlle Ret & Fabien Schweighoffer & Bruno Tocqué & Marie-Thérèse Bluet-Pajot & Valérie Cormier & François Daut, 1998. "Imprinted gene in postnatal growth role," Nature, Nature, vol. 393(6681), pages 125-126, May.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6681:d:10.1038_30120
    DOI: 10.1038/30120
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    Cited by:

    1. Anne-Lyse Denizot & Vanessa Besson & Rosa Maria Correra & Alessia Mazzola & Izolina Lopes & Jean-Remy Courbard & Giovanna Marazzi & David A Sassoon, 2016. "A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior," PLOS Genetics, Public Library of Science, vol. 12(5), pages 1-20, May.

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