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Transcription sans TBP

Author

Listed:
  • Lynne M. Apone

    (the Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical Center)

  • Michael R. Green

    (the Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical Center)

Abstract

Several general ‘rules’ have emerged over the years about the requirements for transcription of genes. One of these was that the TATA-binding protein (TBP) is essential, both for initiation of transcription by recognizing the promoter, and for assembly of transcription complexes. A new study looks set to overturn this dogma by identifying a complex that does not contain TBP (the so-called TBP-free TAFII-containing complex, TFTC) yet can still support transcription.

Suggested Citation

  • Lynne M. Apone & Michael R. Green, 1998. "Transcription sans TBP," Nature, Nature, vol. 393(6681), pages 114-115, May.
  • Handle: RePEc:nat:nature:v:393:y:1998:i:6681:d:10.1038_30097
    DOI: 10.1038/30097
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