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Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

Author

Listed:
  • Yun Qiu

    (Case Western Reserve University, School of Medicine)

  • Lakshmeswari Ravi

    (Case Western Reserve University, School of Medicine)

  • Hsing-Jien Kung

    (Case Western Reserve University, School of Medicine
    National Health Research Institutes)

Abstract

Interleukin-6 (IL-6) is a cytokine that was initially recognized as a regulator of immune and inflammatory responses1, but it also regulates the growth of many tumour cells, including prostrate carcinoma2,3,4. Overexpression of the growth-factor receptors ErbB2/neu and ErbB3 has been implicated in the neoplastic transformation of prostate carcinoma5,6,7. Here we show that treatment of the prostate cancer cell line LNCaP with IL-6 induces tyrosine phosphorylation of ErbB2 and ErbB3, but not ErbB1/EGFR. We also show that ErbB2 forms a complex with the gp130 subunit of the IL-6 receptor in an IL-6-dependent manner. This association is important because the inhibition of ErbB2 activity results in abrogation of IL-6-induced MAPK activation. Thus ErbB2 is a critical component of IL-6 signalling through the MAP kinase pathway. These data show how a cytokine receptor can diversify its signalling pathways by engaging with a growth-factor receptor kinase.

Suggested Citation

  • Yun Qiu & Lakshmeswari Ravi & Hsing-Jien Kung, 1998. "Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells," Nature, Nature, vol. 393(6680), pages 83-85, May.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6680:d:10.1038_30012
    DOI: 10.1038/30012
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