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Hypothalamic CART is a new anorectic peptide regulated by leptin

Author

Listed:
  • Peter Kristensen

    (Health Care Discovery, Novo Nordisk A/S)

  • Martin E. Judge

    (Health Care Discovery, Novo Nordisk A/S)

  • Lars Thim

    (Health Care Discovery, Novo Nordisk A/S)

  • Ulla Ribel

    (Health Care Discovery, Novo Nordisk A/S)

  • Kennet N. Christjansen

    (Health Care Discovery, Novo Nordisk A/S)

  • Birgitte S. Wulff

    (Health Care Discovery, Novo Nordisk A/S)

  • Jes T. Clausen

    (Health Care Discovery, Novo Nordisk A/S)

  • Per B. Jensen

    (Hagedorn Research Institute)

  • Ole D. Madsen

    (Hagedorn Research Institute)

  • Niels Vrang

    (University of Copenhagen)

  • Philip J. Larsen

    (University of Copenhagen)

  • Sven Hastrup

    (Health Care Discovery, Novo Nordisk A/S)

Abstract

The mammalian hypothalamus strongly influences ingestive behaviour through several different signalling molecules and receptor systems1,2,3,4. Here we show that CART (cocaine- and amphetamine-regulated transcript), a brain-located peptide5,6,7,8, is a satiety factor and is closely associated with the actions of two important regulators of food intake, leptin and neuropeptide Y. Food-deprived animals show a pronounced decrease in expression of CART messenger RNA in the arcuate nucleus. In animal models of obesity with disrupted leptin signalling, CART mRNA is almost absent from the arcuate nucleus. Peripheral administration of leptin to obese mice stimulates CART mRNA expression. When injected intracerebroventricularly into rats, recombinant CART peptide inhibits both normal and starvation-induced feeding, and completely blocks the feeding response induced by neuropeptide Y. An antiserum against CART increases feeding in normal rats, indicating that CART may be an endogenous inhibitor of food intake in normal animals.

Suggested Citation

  • Peter Kristensen & Martin E. Judge & Lars Thim & Ulla Ribel & Kennet N. Christjansen & Birgitte S. Wulff & Jes T. Clausen & Per B. Jensen & Ole D. Madsen & Niels Vrang & Philip J. Larsen & Sven Hastru, 1998. "Hypothalamic CART is a new anorectic peptide regulated by leptin," Nature, Nature, vol. 393(6680), pages 72-76, May.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6680:d:10.1038_29993
    DOI: 10.1038/29993
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    Cited by:

    1. Erin Golden & Ana Emiliano & Stuart Maudsley & B Gwen Windham & Olga D Carlson & Josephine M Egan & Ira Driscoll & Luigi Ferrucci & Bronwen Martin & Mark P Mattson, 2010. "Circulating Brain-Derived Neurotrophic Factor and Indices of Metabolic and Cardiovascular Health: Data from the Baltimore Longitudinal Study of Aging," PLOS ONE, Public Library of Science, vol. 5(4), pages 1-9, April.
    2. Le’an Qu & Zhenjie Chen & Manchun Li, 2019. "CART-RF Classification with Multifilter for Monitoring Land Use Changes Based on MODIS Time-Series Data: A Case Study from Jiangsu Province, China," Sustainability, MDPI, vol. 11(20), pages 1-23, October.

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