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The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster

Author

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  • Nina M. Brooke

    (School of Animal and Microbial Sciences, University of Reading)

  • Jordi Garcia-Fernàndez

    (Departament de Gentica, Facultat de Biologia, Universitat de Barcelona)

  • Peter W. H. Holland

    (School of Animal and Microbial Sciences, University of Reading)

Abstract

Genes of the Hox cluster are restricted to the animal kingdom and play a central role in axial patterning in divergent animal phyla1. Despite its evolutionary and developmental significance, the origin of the Hox gene cluster is obscure. The consensus is that a primordial Hox cluster arose by tandem gene duplication close to animal origins2,3,4,5. Several homeobox genes with high sequence identity to Hox genes are found outside the Hox cluster and are known as ‘dispersed’ Hox-like genes; these genes may have been transposed away from an expanding cluster6. Here we show that three of these dispersed homeobox genes form a novel gene cluster in the cephalochordate amphioxus. We argue that this ‘ParaHox’ gene cluster is an ancient paralogue (evolutionary sister) of the Hox gene cluster; the two gene clusters arose by duplication of a ProtoHox gene cluster. Furthermore, we show that amphioxus ParaHox genes have co-linear developmental expression patterns in anterior, middle and posterior tissues. We propose that the origin of distinct Hox and ParaHox genes by gene-cluster duplication facilitated an increase in body complexity during the Cambrian explosion.

Suggested Citation

  • Nina M. Brooke & Jordi Garcia-Fernàndez & Peter W. H. Holland, 1998. "The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster," Nature, Nature, vol. 392(6679), pages 920-922, April.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6679:d:10.1038_31933
    DOI: 10.1038/31933
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    Cited by:

    1. Xavier Grau-Bové & Lucie Subirana & Lydvina Meister & Anaël Soubigou & Ana Neto & Anamaria Elek & Silvia Naranjo & Oscar Fornas & Jose Luis Gomez-Skarmeta & Juan J. Tena & Manuel Irimia & Stéphanie Be, 2024. "An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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