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Premenstrual steroids?

Author

Listed:
  • Karen T. Britton

    (Veterans Administration Medical Center and University of California)

  • George F. Koob

    (The Scripps Research Institute)

Abstract

The symptoms of premenstrual syndrome include depressed mood and anxiety, and the molecular mechanisms behind this are now becoming clear. During menstruation, levels of progesterone fall, and, as a result, so do levels of the progesterone metabolite allopregnanolone. Using a rat model, the authors have found that when production of allopregnanolone is blocked, increased levels of the α4 subunit of the GABAAreceptor are produced. This changes the sensitivity of the receptor to endogenous ligands, resulting in the symptoms associated with premenstrual syndrome.

Suggested Citation

  • Karen T. Britton & George F. Koob, 1998. "Premenstrual steroids?," Nature, Nature, vol. 392(6679), pages 869-870, April.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6679:d:10.1038_31816
    DOI: 10.1038/31816
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