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Putting the Parkin into Parkinson's

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  • Robert L. Nussbaum

    (the National Human Genome Research Institute)

Abstract

Parkinson's disease is characterized by parkinsonism — rigidity, resting tremor and slowness in initiating and carrying out movement. The gene for a rare autosomal recessive form of parkinsonism (AR-JP) has now been cloned and, although AR-JP differs in some respects from Parkinson's disease, the new gene could help to shed light on the causes of Parkinson's. Termedparkin, the gene has a ubiquitin homology domain, indicating that a defect in proteasome function could be involved in Parkinson's disease.

Suggested Citation

  • Robert L. Nussbaum, 1998. "Putting the Parkin into Parkinson's," Nature, Nature, vol. 392(6676), pages 544-545, April.
  • Handle: RePEc:nat:nature:v:392:y:1998:i:6676:d:10.1038_33271
    DOI: 10.1038/33271
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