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Human CD14 mediates recognition and phagocytosis of apoptotic cells

Author

Listed:
  • Andrew Devitt

    (University of Birmingham Medical School
    Institute of Cell Signalling and School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre)

  • Odette D. Moffatt

    (University of Birmingham Medical School
    Institute of Cell Signalling and School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre)

  • Chandra Raykundalia

    (University of Birmingham Medical School)

  • J. Donald Capra

    (Oklahoma Medical Research Foundation)

  • David L. Simmons

    (SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North)

  • Christopher D. Gregory

    (University of Birmingham Medical School
    Institute of Cell Signalling and School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre)

Abstract

Cells undergoing programmed cell death (apoptosis) are cleared rapidly in vivo by phagocytes without inducing inflammation1. Here we show that the glycosylphosphatidylinositol-linked plasma-membrane glycoprotein CD14 (refs 2, 3) on the surface of human macrophages is important for the recognition and clearance of apoptotic cells. CD14 can also act as a receptor that binds bacterial lipopolysaccharide (LPS), triggering inflammatory responses4. Overstimulation of CD14 by LPS can cause the often fatal toxic-shock syndrome5,6. Here we show that apoptotic cells interact with CD14, triggering phagocytosis of the apoptotic cells. This interaction depends on a region of CD14 that is identical to, or at least closely associated with, a region known to bind LPS. However, apoptotic cells, unlike LPS, do not provoke the release of pro-inflammatory cytokines from macrophages. These results indicate that clearance of apoptotic cells is mediated by a receptor whose interactions with ‘non-self’ components (LPS) and ‘self’ components (apoptotic cells) produce distinct macrophage responses.

Suggested Citation

  • Andrew Devitt & Odette D. Moffatt & Chandra Raykundalia & J. Donald Capra & David L. Simmons & Christopher D. Gregory, 1998. "Human CD14 mediates recognition and phagocytosis of apoptotic cells," Nature, Nature, vol. 392(6675), pages 505-509, April.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6675:d:10.1038_33169
    DOI: 10.1038/33169
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    Cited by:

    1. MY Areeshi & Raju K Mandal & Aditya K Panda & Shekhar C Bisht & Shafiul Haque, 2013. "CD14 −159 C>T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
    2. Z. Sladek & D. Rysanek, 2008. "Expression of macrophage CD14 receptor in the course of experimental inflammatory responses induced by lipopolysaccharide and muramyl dipeptide," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 53(7), pages 347-357.

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