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A checkpoint on the road to cancer

Author

Listed:
  • Terry L. Orr-Weaver

    (MIT)

  • Robert A. Weinberg

    (MIT)

Abstract

Mutations that disrupt a cell-division checkpoint, thereby causing alterations in chromosome number, have been identified in cancer cells. The accompanying increase in mutability helps to explain how tumours acquire large numbers of mutant genes during their development.

Suggested Citation

  • Terry L. Orr-Weaver & Robert A. Weinberg, 1998. "A checkpoint on the road to cancer," Nature, Nature, vol. 392(6673), pages 223-224, March.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6673:d:10.1038_32520
    DOI: 10.1038/32520
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    Cited by:

    1. Wei-Yi Cheng & Tai-Hsien Ou Yang & Dimitris Anastassiou, 2013. "Biomolecular Events in Cancer Revealed by Attractor Metagenes," PLOS Computational Biology, Public Library of Science, vol. 9(2), pages 1-14, February.
    2. Paul R. Rosenbaum, 2004. "The Case-Only Odds Ratio as a Causal Parameter," Biometrics, The International Biometric Society, vol. 60(1), pages 233-240, March.

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