IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v392y1998i6671d10.1038_32049.html
   My bibliography  Save this article

Chaperoning brain diseases

Author

Listed:
  • William J. Welch

    (Medicine and Physiology, University of California at San Francisco)

  • Pierluigi Gambetti

    (Institute of Pathology, Case Western Reserve University)

Abstract

Prion diseases and neurodegenerative conditions such as Alzheimer's and Parkinson's have much in common — both seem to involve proteins which, when destabilized by (for example) genetic mutations, change conformation to form insoluble, pathogenic aggregates. Two papers now ask whether molecular chaperones might be involved in these folding changes, and they show that heat-shock proteins and prions can, indeed, interact in vitro.

Suggested Citation

  • William J. Welch & Pierluigi Gambetti, 1998. "Chaperoning brain diseases," Nature, Nature, vol. 392(6671), pages 23-24, March.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6671:d:10.1038_32049
    DOI: 10.1038/32049
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/32049
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/32049?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:392:y:1998:i:6671:d:10.1038_32049. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.