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Key clockwork component cloned

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  • Richard W. Tsien

    (Stanford University Medical Center)

Abstract

The body has many repetitive electrical activities — such as brain waves — that depend on the rhythmic firing of neurons. This is achieved, in part, by the action of T-type calcium channels, inappropriate activity of which can lead to epileptic seizures. Understanding of how these channels work should now be advanced with the cloning of one T-type subunit, known as α1G. And this could lead to the development of agents that treat hypertension by specifically blocking these channels.

Suggested Citation

  • Richard W. Tsien, 1998. "Key clockwork component cloned," Nature, Nature, vol. 391(6670), pages 839-841, February.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6670:d:10.1038_35981
    DOI: 10.1038/35981
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