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A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

Author

Listed:
  • Michael D. Gunn

    (Cardiovascular Research Institute)

  • Vu N. Ngo

    (University of California at San Francisco)

  • K. Mark Ansel

    (University of California at San Francisco)

  • Eric H. Ekland

    (University of California at San Francisco)

  • Jason G. Cyster

    (University of California at San Francisco)

  • Lewis T. Williams

    (Cardiovascular Research Institute
    Chiron Corporation)

Abstract

Secondary lymphoid organs (spleen, lymph nodes and Peyer's patches) are divided into compartments, such as B-cell zones (follicles) and T-cell zones, which provide specialized environments for specific steps of the immune response. Migration of lymphocyte subsets into these compartments is essential for normal immune function, yet the molecular cues guiding this cellular traffic are poorly defined. Chemokines constitute a family of chemotactic cytokines that have been shown to direct the migration of leukocytes during inflammation1,2 and which may be involved in the constitutive homing of lymphocytes into follicles and T-cell zones3,4,5,6,7,8. Here we describe a novel chemokine, B-lymphocyte chemoattractant (BLC), that is strongly expressed in the follicles of Peyer's patches, the spleen and lymph nodes. BLC strongly attracts B lymphocytes while promoting migration of only small numbers of T cells and macrophages, and therefore is the first chemokine to be identified that is selective towards B cells. An orphan chemokine receptor, Burkitt's lymphoma receptor 1 (BLR-1), has been found to be required for B-cell migration into lymphoid follicles6. We show that BLC stimulates calcium influx into, and chemotaxis of, cells transfected with BLR-1. Our results indicate that BLC functions as a BLR-1 ligand and may guide B lymphocytes to follicles in secondary lymphoid organs.

Suggested Citation

  • Michael D. Gunn & Vu N. Ngo & K. Mark Ansel & Eric H. Ekland & Jason G. Cyster & Lewis T. Williams, 1998. "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1," Nature, Nature, vol. 391(6669), pages 799-803, February.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6669:d:10.1038_35876
    DOI: 10.1038/35876
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    1. Takuya Harada & Yoshikane Kikushige & Toshihiro Miyamoto & Kazuko Uno & Hiroaki Niiro & Atsushi Kawakami & Tomohiro Koga & Koichi Akashi & Kazuyuki Yoshizaki, 2023. "Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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