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Dax1 antagonizes Sry action in mammalian sex determination

Author

Listed:
  • Amanda Swain

    (MRC National Institute for Medical Research)

  • Veronica Narvaez

    (MRC National Institute for Medical Research
    Facultad de Ciencias, Universidad Autonoma del Estado de Morelos)

  • Paul Burgoyne

    (MRC National Institute for Medical Research)

  • Giovanna Camerino

    (Biologia Generale e Genetica Medica, Universita di Pavia)

  • Robin Lovell-Badge

    (MRC National Institute for Medical Research)

Abstract

DAX1, which encodes an unusual member of the nuclear hormone-receptor superfamily, is a gene that may be responsible for a sex-reversal syndrome in humans, referred to as dosage-sensitive sex reversal, in which XY individuals carrying duplications of Xp21, part of the small arm of the X chromosome, develop as females. XY mice carrying extra copies of mouse Dax1 as a transgene show delayed testis development when the gene is expressed at high levels, but do not normally show sex reversal. Complete sex reversal occurs, however, when the transgene is tested against weak alleles of the sex-determining Y-chromosome gene Sry. These results show that DAX1 is largely, if not solely, responsible for dosage-sensitive sex reversal and provide a model for early events in mammalian sex determination, when precise levels and timing of gene expression are critical.

Suggested Citation

  • Amanda Swain & Veronica Narvaez & Paul Burgoyne & Giovanna Camerino & Robin Lovell-Badge, 1998. "Dax1 antagonizes Sry action in mammalian sex determination," Nature, Nature, vol. 391(6669), pages 761-767, February.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6669:d:10.1038_35799
    DOI: 10.1038/35799
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    Cited by:

    1. Clive H Glover & Michael Marin & Connie J Eaves & Cheryl D Helgason & James M Piret & Jennifer Bryan, 2006. "Meta-Analysis of Differentiating Mouse Embryonic Stem Cell Gene Expression Kinetics Reveals Early Change of a Small Gene Set," PLOS Computational Biology, Public Library of Science, vol. 2(11), pages 1-12, November.
    2. D. Nak & T. Gulten & M. Karkucak & R. Yilmaz & Y. Nak & G. Simsek & A.H. Shahzad, 2015. "SRY-negative XX sex reversal in an English Cocker Spaniel: a case report," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 60(3), pages 170-173.

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