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Immunology Signal sequences stop killer cells

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  • Eric O. Long

    (Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

During protein synthesis, many proteins destined to be carried to the cell surface are tagged with a so-called signal sequence which guides their translocation into the endoplasmic reticulum. Once that job had been done, such sequences were thought to be redundant. A striking and unexpected twist comes in the form of the discovery that signal sequences have a highly specific function in immune recognition through the agency of class I molecules of the major histocompatibility complex. It turns out that they have a central place in controlling the tolerance of types of lymphocytes known as natural killer cells to the body's own tissues.

Suggested Citation

  • Eric O. Long, 1998. "Immunology Signal sequences stop killer cells," Nature, Nature, vol. 391(6669), pages 741-743, February.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6669:d:10.1038_35739
    DOI: 10.1038/35739
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