IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v391y1998i6668d10.1038_35515.html
   My bibliography  Save this article

Unmasking the killer's accomplice

Author

Listed:
  • Marco Colonna

    (Marco Colonna is at the Basel Institute for Immunology)

Abstract

One way in which our immune system detects virally infected cells is by monitoring levels of class I major histocompatibility complex (MHC). In infected cells, class I expression is downregulated, acting as a signal to the natural killer (NK) cells to target that cell for destruction. But some class I homologues stimulate — rather than inhibit — the NK cells, and one group has now found out why. They have discovered a signal-transducing adaptor molecule called DAP12, which couples recognition of class I MHC to an activating signal-transduction pathway.

Suggested Citation

  • Marco Colonna, 1998. "Unmasking the killer's accomplice," Nature, Nature, vol. 391(6668), pages 642-643, February.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6668:d:10.1038_35515
    DOI: 10.1038/35515
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35515
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35515?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:391:y:1998:i:6668:d:10.1038_35515. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.