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Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana

Author

Listed:
  • The EU Arabidopsis Genome Project
  • M. Bevan

    (John Innes Centre)

  • I. Bancroft

    (John Innes Centre)

  • E. Bent

    (John Innes Centre)

  • K. Love

    (John Innes Centre)

  • H. Goodman

    (Harvard Medical School)

  • C. Dean

    (John Innes Centre)

  • R. Bergkamp

    (CPRO-DLO)

  • W. Dirkse

    (CPRO-DLO)

  • M. Van Staveren

    (CPRO-DLO)

  • W. Stiekema

    (CPRO-DLO)

  • L. Drost

    (John Innes Centre)

  • P. Ridley

    (John Innes Centre)

  • S.-A. Hudson

    (John Innes Centre)

  • K. Patel

    (John Innes Centre)

  • G. Murphy

    (John Innes Centre)

  • P. Piffanelli

    (John Innes Centre)

  • H. Wedler

    (AGOWA GmbH)

  • E. Wedler

    (AGOWA GmbH)

  • R. Wambutt

    (AGOWA GmbH)

  • T. Weitzenegger

    (GATC GmbH)

  • T. M. Pohl

    (GATC GmbH)

  • N. Terryn

    (Vlaams Interuniversitair Instituut voor Biotechnologie, Universiteit Gent)

  • J. Gielen

    (Vlaams Interuniversitair Instituut voor Biotechnologie, Universiteit Gent)

  • R. Villarroel

    (Vlaams Interuniversitair Instituut voor Biotechnologie, Universiteit Gent)

  • R. De Clerck

    (Vlaams Interuniversitair Instituut voor Biotechnologie, Universiteit Gent)

  • M. Van Montagu

    (Vlaams Interuniversitair Instituut voor Biotechnologie, Universiteit Gent)

  • A. Lecharny

    (Institut de Biotechnologie des Plantes, Université de Paris-Sud)

  • S. Auborg

    (Institut de Biotechnologie des Plantes, Université de Paris-Sud)

  • I. Gy

    (Institut de Biotechnologie des Plantes, Université de Paris-Sud)

  • M. Kreis

    (Institut de Biotechnologie des Plantes, Université de Paris-Sud)

  • N. Lao

    (Trinity College)

  • T. Kavanagh

    (Trinity College)

  • S. Hempel

    (SRD GmbH)

  • P. Kotter

    (SRD GmbH)

  • K.-D. Entian

    (SRD GmbH)

  • M. Rieger

    (Genotype GmbH)

  • M. Schaeffer

    (Genotype GmbH)

  • B. Funk

    (Genotype GmbH)

  • S. Mueller-Auer

    (Genotype GmbH)

  • M. Silvey

    (School of Biological Sciences, University of East Anglia)

  • R. James

    (School of Biological Sciences, University of East Anglia)

  • A. Montfort

    (CSIC)

  • A. Pons

    (CSIC)

  • P. Puigdomenech

    (CSIC)

  • A. Douka

    (Agricultural University of Athens)

  • E. Voukelatou

    (Agricultural University of Athens)

  • D. Milioni

    (Agricultural University of Athens)

  • P. Hatzopoulos

    (Agricultural University of Athens)

  • E. Piravandi

    (MediGene AG)

  • B. Obermaier

    (MediGene AG)

  • H. Hilbert

    (QIAGEN GmbH)

  • A. Düsterhöft

    (QIAGEN GmbH)

  • T. Moores

    (The Sainsbury Laboratory, John Innes Centre)

  • J. D. G. Jones

    (The Sainsbury Laboratory, John Innes Centre)

  • T. Eneva

    (Max-Delbruck-Laboratorium in der Max-Planck Gesellschaft)

  • K. Palme

    (Max-Delbruck-Laboratorium in der Max-Planck Gesellschaft)

  • V. Benes

    (European Molecular Biology Laboratory)

  • S. Rechman

    (European Molecular Biology Laboratory)

  • W. Ansorge

    (European Molecular Biology Laboratory)

  • R. Cooke

    (UMR CNRS 5545, Université Perpignan)

  • C. Berger

    (UMR CNRS 5545, Université Perpignan)

  • M. Delseny

    (UMR CNRS 5545, Université Perpignan)

  • M. Voet

    (Laboratory of Gene Technology, Katholieke Universiteit Leuven)

  • G. Volckaert

    (Laboratory of Gene Technology, Katholieke Universiteit Leuven)

  • H.-W. Mewes

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck Institut für Biochemie)

  • S. Klosterman

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck Institut für Biochemie)

  • C. Schueller

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck Institut für Biochemie)

  • N. Chalwatzis

    (Martinsrieder Institut für Protein Sequenzen, Max-Planck Institut für Biochemie)

Abstract

The plant Arabidopsis thaliana (Arabidopsis) has become an important model species for the study of many aspects of plant biology1. The relatively small size of the nuclear genome and the availability of extensive physical maps of the five chromosomes2,3,4 provide a feasible basis for initiating sequencing of the five chromosomes. The YAC (yeast artificial chromosome)-based physical map of chromosome 4 was used to construct a sequence-ready map of cosmid and BAC (bacterial artificial chromosome) clones covering a 1.9-megabase (Mb) contiguous region5, and the sequence of this region is reported here. Analysis of the sequence revealed an average gene density of one gene every 4.8 kilobases (kb), and 54% of the predicted genes had significant similarity to known genes. Other interesting features were found, such as the sequence of a disease-resistance gene locus, the distribution of retroelements, the frequent occurrence of clustered gene families, and the sequence of several classes of genes not previously encountered in plants.

Suggested Citation

  • The EU Arabidopsis Genome Project & M. Bevan & I. Bancroft & E. Bent & K. Love & H. Goodman & C. Dean & R. Bergkamp & W. Dirkse & M. Van Staveren & W. Stiekema & L. Drost & P. Ridley & S.-A. Hudson & , 1998. "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana," Nature, Nature, vol. 391(6666), pages 485-488, January.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6666:d:10.1038_35140
    DOI: 10.1038/35140
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