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Stimulation by Rad52 of yeast Rad51- mediated recombination

Author

Listed:
  • Akira Shinohara

    (Graduate School of Science, Osaka University)

  • Tomoko Ogawa

    (National Institute of Genetics)

Abstract

In Saccharomyces cerevisiae, the RAD51 and RAD52 genes are involved in recombination and in repair of damaged DNA1,2,3. The RAD51 gene is a structural and functional homologue of the recA gene4,5 and the gene product participates in strand exchange and single-stranded-DNA-dependent ATP hydrolysis by means of nucleoprotein filament formation6,7,8,9,10,11. The RAD52 gene12 is important in RAD51-mediated recombination1,2,3. Binding of this protein to Rad51 (refs 4, 13) suggests that they cooperate in recombination. Homologues of both Rad51 and Rad52 are conserved from yeast to humans14,15,16, suggesting that the mechanisms used for pairing homologous DNA molecules during recombination may be universal in eukaryotes. Here we show that Rad52 protein stimulates Rad51 reactions and that binding to Rad51 is necessary for this stimulatory effect. We conclude that this binding is crucial in recombination and that it facilitates the formation of Rad51 nucleoprotein filaments.

Suggested Citation

  • Akira Shinohara & Tomoko Ogawa, 1998. "Stimulation by Rad52 of yeast Rad51- mediated recombination," Nature, Nature, vol. 391(6665), pages 404-407, January.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6665:d:10.1038_34943
    DOI: 10.1038/34943
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    Cited by:

    1. Xiao, Qian & Xu, Hongquan, 2021. "A mapping-based universal Kriging model for order-of-addition experiments in drug combination studies," Computational Statistics & Data Analysis, Elsevier, vol. 157(C).
    2. Masaru Ito & Asako Furukohri & Kenichiro Matsuzaki & Yurika Fujita & Atsushi Toyoda & Akira Shinohara, 2023. "FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Guangxue Liu & Jimin Li & Boxue He & Jiaqi Yan & Jingyu Zhao & Xuejie Wang & Xiaocong Zhao & Jingyan Xu & Yeyao Wu & Simin Zhang & Xiaoli Gan & Chun Zhou & Xiangpan Li & Xinghua Zhang & Xuefeng Chen, 2023. "Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Shengli Zhao & Zehui Dong & Yuna Zhao, 2022. "Order-of-Addition Orthogonal Arrays with High Strength," Mathematics, MDPI, vol. 10(7), pages 1-17, April.
    5. Chen, Jianbin & Mukerjee, Rahul & Lin, Dennis K.J., 2020. "Construction of optimal fractional Order-of-Addition designs via block designs," Statistics & Probability Letters, Elsevier, vol. 161(C).

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