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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Author

Listed:
  • Andrei Glinka

    (Deutsches Krebsforschungszentrum)

  • Wei Wu

    (Deutsches Krebsforschungszentrum)

  • Hajo Delius

    (Deutsches Krebsforschungszentrum)

  • A. Paula Monaghan

    (Deutsches Krebsforschungszentrum)

  • Claudia Blumenstock

    (Deutsches Krebsforschungszentrum)

  • Christof Niehrs

    (Deutsches Krebsforschungszentrum)

Abstract

The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.

Suggested Citation

  • Andrei Glinka & Wei Wu & Hajo Delius & A. Paula Monaghan & Claudia Blumenstock & Christof Niehrs, 1998. "Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction," Nature, Nature, vol. 391(6665), pages 357-362, January.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6665:d:10.1038_34848
    DOI: 10.1038/34848
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