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CCR5 is characteristic of Th1 lymphocytes

Author

Listed:
  • Pius Loetscher

    (University Hospital)

  • Mariagrazia Uguccioni

    (Theodor-Kocher Institute, University of Bern)

  • Lorenza Bordoli

    (Theodor-Kocher Institute, University of Bern)

  • Marco Baggiolini

    (Theodor-Kocher Institute, University of Bern)

  • Bernhard Moser

    (Theodor-Kocher Institute, University of Bern)

  • Carlo Chizzolini

    (University Hospital)

  • Jean-Michel Dayer

    (University Hospital)

Abstract

CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites. Th2 lymphocytes preferentially express the chemokine receptor CCR3 (23). We have studied the occurrence of two additional chemokine receptors, CCR5 and CXCR3, in human, antigen-specific CD4+ Th1 and Th2 cell clones4.

Suggested Citation

  • Pius Loetscher & Mariagrazia Uguccioni & Lorenza Bordoli & Marco Baggiolini & Bernhard Moser & Carlo Chizzolini & Jean-Michel Dayer, 1998. "CCR5 is characteristic of Th1 lymphocytes," Nature, Nature, vol. 391(6665), pages 344-345, January.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6665:d:10.1038_34814
    DOI: 10.1038/34814
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