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Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

Author

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  • Marina R. Picciotto

    (CNRS UA D1284, Neurobiologie Moléculaire, Institut Pasteur
    Yale University School of Medicine)

  • Michele Zoli

    (CNRS UA D1284, Neurobiologie Moléculaire, Institut Pasteur
    Section of Physiology, University of Modena)

  • Roberto Rimondini

    (Karolinska Institute)

  • Clément Léna

    (CNRS UA D1284, Neurobiologie Moléculaire, Institut Pasteur)

  • Lisa M. Marubio

    (CNRS UA D1284, Neurobiologie Moléculaire, Institut Pasteur)

  • Emilio Merlo Pich

    (Geneva Biomedical Research Institute, Glaxo-Wellcome R&D)

  • Kjell Fuxe

    (Karolinska Institute)

  • Jean-Pierre Changeux

    (CNRS UA D1284, Neurobiologie Moléculaire, Institut Pasteur)

Abstract

Release of the neurotransmitter dopamine in the mesolimbic system of the brain mediates the reinforcing properties of several drugs of abuse, including nicotine1. Here we investigate the contribution of the high-affinity neuronal nicotinic acetylcholine receptor2 to the effects of nicotine on the mesolimbic dopamine system in mice lacking the β2 subunit of this receptor3. We found that nicotine stimulates dopamine release in the ventral striatum of wild-type mice but not in the ventral striatum of β2-mutant mice. Using patch-clamp recording, we show that mesencephalic dopaminergic neurons from mice without the β2 subunit no longer respond to nicotine, and that self-administration of nicotine is attenuated in these mutant mice. Our results strongly support the idea that the β2-containing neuronal nicotinic acetylcholine receptor is involved in mediating the reinforcing properties of nicotine.

Suggested Citation

  • Marina R. Picciotto & Michele Zoli & Roberto Rimondini & Clément Léna & Lisa M. Marubio & Emilio Merlo Pich & Kjell Fuxe & Jean-Pierre Changeux, 1998. "Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine," Nature, Nature, vol. 391(6663), pages 173-177, January.
    • Handle: RePEc:nat:nature:v:391:y:1998:i:6663:d:10.1038_34413
    DOI: 10.1038/34413
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    1. Panagis Galiatsatos & MopeninuJesu Oluyinka & Jihyun Min & Raiza Schreiber & Dina G. Lansey & Ruth Ikpe & Manuel C. Pacheco & Victoria DeJaco & Alejandra Ellison-Barnes & Enid Neptune & Norma F. Kanar, 2022. "Prevalence of Mental Health and Social Connection among Patients Seeking Tobacco Dependence Management: A Pilot Study," IJERPH, MDPI, vol. 19(18), pages 1-9, September.

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