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B lymphocytes and neuroinvasion

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  • Paul Brown

    (the Laboratory of CNS Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health)

Abstract

How does consumption of meat products infected with bovine spongiform encephalopathy (BSE) lead to development of Creutzfeldt-Jakob disease (CJD)? Studies of the brain, spleen and marrow of many immunodeficient mouse lines indicate that differentiated B lymphocytes are important for neuroinvasion. This discovery has implications for therapies against CJD, and also for the broader public-health issue of screening blood products against possible infection.

Suggested Citation

  • Paul Brown, 1997. "B lymphocytes and neuroinvasion," Nature, Nature, vol. 390(6661), pages 662-663, December.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6661:d:10.1038_37733
    DOI: 10.1038/37733
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