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Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

Author

Listed:
  • Emanuel F. Petricoin

    (Center for Biologics, Evaluation and Research, FDA)

  • Satoshi Ito

    (Center for Biologics, Evaluation and Research, FDA)

  • Brandi L. Williams

    (Mayo Clinic)

  • Susette Audet

    (Center for Biologics, Evaluation and Research, FDA)

  • Louis F. Stancato

    (Center for Biologics, Evaluation and Research, FDA)

  • Ana Gamero

    (Research Institute, Cleveland Clinic Foundation)

  • Kathleen Clouse

    (Center for Biologics, Evaluation and Research, FDA)

  • Philip Grimley

    (USUHS)

  • Arthur Weiss

    (University of California at San Francisco)

  • Judy Beeler

    (Center for Biologics, Evaluation and Research, FDA)

  • David S. Finbloom

    (Center for Biologics, Evaluation and Research, FDA)

  • Elizabeth W. Shores

    (Center for Biologics, Evaluation and Research, FDA)

  • Robert Abraham

    (Mayo Clinic)

  • Andrew C. Larner

    (Center for Biologics, Evaluation and Research, FDA
    University of California at San Francisco)

Abstract

Signal transduction through both cytokine and lymphocyte antigen receptors shares some common pathways by which they initiate cellular responses, such as activation of mitogen-activated protein kinase(s)1,2. However, other signalling components appear to be uniquely coupled to each receptor. For example, the interferon receptors transduce regulatory signals through the JAK/STAT pathway, resulting in an inhibition of growth and of antiviral effects, whereas this pathway apparently plays no role in T-cell-receptor (TCR)-dependent gene expression3,4. Conversely, signal transduction through the TCR requires the tyrosine kinases Lck and ZAP-70 and the tyrosine phosphatase CD45 (ref. 5). Here we show that, unexpectedly, transmission of growth-inhibitory signals by interferon-α (IFN-α) in T cells requires the expression and association of CD45, Lck and ZAP-70 with the IFN-α-receptor signalling complex.

Suggested Citation

  • Emanuel F. Petricoin & Satoshi Ito & Brandi L. Williams & Susette Audet & Louis F. Stancato & Ana Gamero & Kathleen Clouse & Philip Grimley & Arthur Weiss & Judy Beeler & David S. Finbloom & Elizabeth, 1997. "Antiproliferative action of interferon-α requires components of T-cell-receptor signalling," Nature, Nature, vol. 390(6660), pages 629-632, December.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6660:d:10.1038_37648
    DOI: 10.1038/37648
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