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Role of cytosolic phospholipase A2 in allergic response and parturition

Author

Listed:
  • Naonori Uozumi

    (Geriatrics, Faculty of Medicine, University of Tokyo)

  • Kazuhiko Kume

    (Geriatrics, Faculty of Medicine, University of Tokyo)

  • Takahide Nagase

    (Faculty of Medicine, University of Tokyo)

  • Noriaki Nakatani

    (Geriatrics, Faculty of Medicine, University of Tokyo)

  • Satoshi Ishii

    (Geriatrics, Faculty of Medicine, University of Tokyo)

  • Fumi Tashiro

    (Institute of Development, Aging and Cancer, Tohoku University
    Osaka University Medical School)

  • Yoshinori Komagata

    (Institute of Development, Aging and Cancer, Tohoku University)

  • Kazushige Maki

    (Disease-related Gene Regulation Research (Sandoz), Faculty of Medicine, University of Tokyo
    Faculty of Medicine, Kyoto University)

  • Koichi Ikuta

    (Disease-related Gene Regulation Research (Sandoz), Faculty of Medicine, University of Tokyo
    Faculty of Medicine, Kyoto University)

  • Yasuyoshi Ouchi

    (Faculty of Medicine, University of Tokyo)

  • Jun-ichi Miyazaki

    (Institute of Development, Aging and Cancer, Tohoku University
    Osaka University Medical School)

  • Takao Shimizu

    (Geriatrics, Faculty of Medicine, University of Tokyo)

Abstract

Phospholipase A2 (PLA2) comprises a superfamily of enzymes that hydrolyse the ester bond of phospholipids at the sn-2 position1,2,3. Among the members of this superfamily, cytosolic PLA2 has attracted attention because it preferentially hydrolyses arachidonoyl phospholipids and is activated by submicromolar concentrations of Ca2+ ions and by phosphorylation by mitogen-activated protein kinases (MAP kinases)4,5,6,7,8. Here we investigate the function of cytosolic PLA2 in vivo by using homologous recombination to generate mice deficient in this enzyme. These mice showed a marked decrease in their production of eicosanoids and platelet-activating factor in peritoneal macrophages. Their ovalbumin-induced anaphylactic responses were significantly reduced, as was their bronchial reactivity to methacholine. Female mutant mice failed to deliver offspring, but these could be rescued by administration of a progesterone-receptor antagonist to the mother at term. Considered together with previous findings9,10,11,12,13,14,15, our results indicate that cytosolic PLA2 plays a non-redundant role in allergic responses and reproductive physiology.

Suggested Citation

  • Naonori Uozumi & Kazuhiko Kume & Takahide Nagase & Noriaki Nakatani & Satoshi Ishii & Fumi Tashiro & Yoshinori Komagata & Kazushige Maki & Koichi Ikuta & Yasuyoshi Ouchi & Jun-ichi Miyazaki & Takao Sh, 1997. "Role of cytosolic phospholipase A2 in allergic response and parturition," Nature, Nature, vol. 390(6660), pages 618-622, December.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6660:d:10.1038_37622
    DOI: 10.1038/37622
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