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Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

Author

Listed:
  • Claire M. Fraser

    (The Institute for Genomic Research)

  • Sherwood Casjens

    (University of Utah)

  • Wai Mun Huang

    (University of Utah)

  • Granger G. Sutton

    (The Institute for Genomic Research)

  • Rebecca Clayton

    (The Institute for Genomic Research)

  • Raju Lathigra

    (MedImmune, Inc.)

  • Owen White

    (The Institute for Genomic Research)

  • Karen A. Ketchum

    (The Institute for Genomic Research)

  • Robert Dodson

    (The Institute for Genomic Research)

  • Erin K. Hickey

    (The Institute for Genomic Research)

  • Michelle Gwinn

    (The Institute for Genomic Research)

  • Brian Dougherty

    (The Institute for Genomic Research)

  • Jean-Francois Tomb

    (The Institute for Genomic Research)

  • Robert D. Fleischmann

    (The Institute for Genomic Research)

  • Delwood Richardson

    (The Institute for Genomic Research)

  • Jeremy Peterson

    (The Institute for Genomic Research)

  • Anthony R. Kerlavage

    (The Institute for Genomic Research)

  • John Quackenbush

    (The Institute for Genomic Research)

  • Steven Salzberg

    (The Institute for Genomic Research)

  • Mark Hanson

    (MedImmune, Inc.)

  • Rene van Vugt

    (University of Utah)

  • Nanette Palmer

    (University of Utah)

  • Mark D. Adams

    (The Institute for Genomic Research)

  • Jeannine Gocayne

    (The Institute for Genomic Research)

  • Janice Weidman

    (The Institute for Genomic Research)

  • Teresa Utterback

    (The Institute for Genomic Research)

  • Larry Watthey

    (The Institute for Genomic Research)

  • Lisa McDonald

    (The Institute for Genomic Research)

  • Patricia Artiach

    (The Institute for Genomic Research)

  • Cheryl Bowman

    (The Institute for Genomic Research)

  • Stacey Garland

    (The Institute for Genomic Research)

  • Claire Fujii

    (The Institute for Genomic Research)

  • Matthew D. Cotton

    (The Institute for Genomic Research)

  • Kurt Horst

    (The Institute for Genomic Research)

  • Kevin Roberts

    (The Institute for Genomic Research)

  • Bonnie Hatch

    (The Institute for Genomic Research)

  • Hamilton O. Smith

    (The Institute for Genomic Research)

  • J. Craig Venter

    (The Institute for Genomic Research)

Abstract

The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular plasmids with a combined size of more than 533,000 base pairs. The chromosome contains 853 genes encoding a basic set of proteins for DNA replication, transcription, translation, solute transport and energy metabolism, but, like Mycoplasma genitalium, it contains no genes for cellular biosynthetic reactions. Because B. burgdorferi and M. genitalium are distantly related eubacteria, we suggest that their limited metabolic capacities reflect convergent evolution by gene loss from more metabolically competent progenitors. Of 430 genes on 11 plasmids, most have no known biological function; 39% of plasmid genes are paralogues that form 47 gene families. The biological significance of the multiple plasmid-encoded genes is not clear, although they may be involved in antigenic variation or immune evasion.

Suggested Citation

  • Claire M. Fraser & Sherwood Casjens & Wai Mun Huang & Granger G. Sutton & Rebecca Clayton & Raju Lathigra & Owen White & Karen A. Ketchum & Robert Dodson & Erin K. Hickey & Michelle Gwinn & Brian Doug, 1997. "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi," Nature, Nature, vol. 390(6660), pages 580-586, December.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6660:d:10.1038_37551
    DOI: 10.1038/37551
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    Cited by:

    1. Constantin N. Takacs & Jenny Wachter & Yingjie Xiang & Zhongqing Ren & Xheni Karaboja & Molly Scott & Matthew R. Stoner & Irnov Irnov & Nicholas Jannetty & Patricia A. Rosa & Xindan Wang & Christine J, 2022. "Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Emily Petroni & Caroline Esnault & Daniel Tetreault & Ryan K. Dale & Gisela Storz & Philip P. Adams, 2023. "Extensive diversity in RNA termination and regulation revealed by transcriptome mapping for the Lyme pathogen Borrelia burgdorferi," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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