IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v390y1997i6660d10.1038_37507.html
   My bibliography  Save this article

An E2F-like repressor of transcription

Author

Listed:
  • M. Morkel

    (Laboratory for Molecular Biology of Pediatric Disease, Charit, Humboldt University)

  • J. Wenkel

    (Laboratory for Molecular Biology of Pediatric Disease, Charit, Humboldt University)

  • A. J. Bannister

    (University of Cambridge)

  • T. Kouzarides

    (University of Cambridge)

  • Christian Hagemeier

    (Charit-Virchow Medical Center, Humboldt University)

Abstract

The activity of a variety of genes whose products are involved in DNA replication and cell-cycle progression are regulated by E2F transcription factors, which bind to E2F sites on DNA in cooperation with members of the DP family of transcription factors1. E2F sites can act as both positive and negative control elements2. Transcriptional activation from E2F sites is mediated by ‘free’ E2F, whereas repression conventionally requires the formation of a complex with a pocket protein (retinoblastoma protein (RB), p107 or p130)3. Here we describe an E2F-like protein, termed EMA (for E2F-binding site modulating activity), which can act as a repressor of transcription without a pocket protein.

Suggested Citation

  • M. Morkel & J. Wenkel & A. J. Bannister & T. Kouzarides & Christian Hagemeier, 1997. "An E2F-like repressor of transcription," Nature, Nature, vol. 390(6660), pages 567-568, December.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6660:d:10.1038_37507
    DOI: 10.1038/37507
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/37507
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/37507?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:390:y:1997:i:6660:d:10.1038_37507. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.