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A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line

Author

Listed:
  • Beilin Zhang

    (University of Wisconsin-Madison)

  • Maria Gallegos

    (University of Wisconsin-Madison)

  • Alessandro Puoti

    (University of Wisconsin-Madison)

  • Eileen Durkin

    (University of Wisconsin-Madison)

  • Stanley Fields

    (Howard Hughes Medical Institute, University of WashingtonSeattle)

  • Judith Kimble

    (University of Wisconsin-Madison
    Howard Hughes Medical Institute, University of WisconsinMadison)

  • Marvin P. Wickens

    (University of Wisconsin-Madison)

Abstract

The nematode Caenorhabditis elegans has two sexes, males and hermaphrodites. Hermaphrodites initially produce sperm but switch to producing oocytes. This switch appears to be controlled by the 3′ untranslated region of fem-3 messenger RNA. We have now identified a binding factor (FBF) which is a cytoplasmic protein that binds specifically to the regulatory region of fem-3 3′UTR and mediates the sperm/oocyte switch. The RNA-binding domain of FBF consists of a stretch of eight tandem repeats and two short flanking regions. This structural element is conserved in several proteins including Drosophila Pumilio, a regulatory protein that controls pattern formation in the fly by binding to a 3′UTR. We propose that FBF and Pumilio are members of a widespread family of sequence-specific RNA-binding proteins.

Suggested Citation

  • Beilin Zhang & Maria Gallegos & Alessandro Puoti & Eileen Durkin & Stanley Fields & Judith Kimble & Marvin P. Wickens, 1997. "A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line," Nature, Nature, vol. 390(6659), pages 477-484, December.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6659:d:10.1038_37297
    DOI: 10.1038/37297
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    Cited by:

    1. Chen Qiu & Zihan Zhang & Robert N. Wine & Zachary T. Campbell & Jun Zhang & Traci M. Tanaka Hall, 2023. "Intra- and inter-molecular regulation by intrinsically-disordered regions governs PUF protein RNA binding," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Christoph Sadée & Lauren D. Hagler & Winston R. Becker & Inga Jarmoskaite & Pavanapuresan P. Vaidyanathan & Sarah K. Denny & William J. Greenleaf & Daniel Herschlag, 2022. "A comprehensive thermodynamic model for RNA binding by the Saccharomyces cerevisiae Pumilio protein PUF4," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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