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Math1 is essential for genesis of cerebellar granule neurons

Author

Listed:
  • Nissim Ben-Arie

    (Departments of Molecular and Human Genetics
    Pediatrics)

  • Hugo J. Bellen

    (Departments of Molecular and Human Genetics
    Cell Biology
    Howard Hughes Medical Institute, Baylor College of Medicine)

  • Dawna L. Armstrong

    (Pathology)

  • Alanna E. McCall

    (Pediatrics)

  • Polina R. Gordadze

    (Pediatrics)

  • Qiuxia Guo

    (Pathology)

  • Martin M. Matzuk

    (Departments of Molecular and Human Genetics
    Cell Biology
    Pathology)

  • Huda Y. Zoghbi

    (Departments of Molecular and Human Genetics
    Pediatrics
    Howard Hughes Medical Institute, Baylor College of Medicine)

Abstract

The cerebellum is essential for fine motor control of movement and posture, and its dysfunction disrupts balance and impairs control of speech, limb and eye movements. The developing cerebellum consists mainly of three types of neuronal cells: granule cells in the external germinal layer, Purkinje cells, and neurons of the deep nuclei1. The molecular mechanisms that underlie the specific determination and the differentiation of each of these neuronal subtypes are unknown. Math1 (refs 2, 3), the mouse homologue of the Drosophila gene atonal4, encodes a basic helix–loop–helix transcription factor that is specifically expressed in the precursors of the external germinal layer and their derivatives. Here we report that mice lacking Math1 fail to form granule cells and are born with a cerebellum that is devoid of an external germinal layer. To our knowledge, Math1 is the first gene to be shown to be required in vivo for the genesis of granule cells, and hence the predominant neuronal population in the cerebellum.

Suggested Citation

  • Nissim Ben-Arie & Hugo J. Bellen & Dawna L. Armstrong & Alanna E. McCall & Polina R. Gordadze & Qiuxia Guo & Martin M. Matzuk & Huda Y. Zoghbi, 1997. "Math1 is essential for genesis of cerebellar granule neurons," Nature, Nature, vol. 390(6656), pages 169-172, November.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6656:d:10.1038_36579
    DOI: 10.1038/36579
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    Cited by:

    1. Tian Wang & Tian Yang & Amanda Kedaigle & Gabriela Pregernig & Ryan McCarthy & Ben Holmes & Xudong Wu & Lars Becker & Ning Pan & Kathy So & Leon Chen & Jun He & Ahmad Mahmoudi & Soumya Negi & Monika K, 2024. "Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Meike E. Heijden & Alejandro G. Rey Hipolito & Linda H. Kim & Dominic J. Kizek & Ross M. Perez & Tao Lin & Roy V. Sillitoe, 2023. "Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Nadine Schroeder & Manuela Wuelling & Daniel Hoffmann & Beate Brand-Saberi & Andrea Vortkamp, 2019. "Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-22, August.

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