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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Author

Listed:
  • Makoto Kuro-o

    (National Institute of Neuroscience, NCNP)

  • Yutaka Matsumura

    (National Institute of Neuroscience, NCNP
    University of Gunma School of Medicine)

  • Hiroki Aizawa

    (National Institute of Neuroscience, NCNP
    University of Gunma School of Medicine)

  • Hiroshi Kawaguchi

    (Faculty of Medicine, University of Tokyo)

  • Tatsuo Suga

    (University of Gunma School of Medicine)

  • Toshihiro Utsugi

    (University of Gunma School of Medicine)

  • Yoshio Ohyama

    (University of Gunma School of Medicine)

  • Masahiko Kurabayashi

    (University of Gunma School of Medicine)

  • Tadashi Kaname

    (Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine)

  • Eisuke Kume

    (Lead Optimization Research Laboratory, Tanabe Seiyaku Co. Ltd)

  • Hitoshi Iwasaki

    (Lead Optimization Research Laboratory, Tanabe Seiyaku Co. Ltd)

  • Akihiro Iida

    (Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd)

  • Takako Shiraki-Iida

    (National Institute of Neuroscience, NCNP
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd)

  • Satoshi Nishikawa

    (Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd)

  • Ryozo Nagai

    (University of Gunma School of Medicine
    Core Research for Evolutional Science & Technology (CREST), JRDC and)

  • Yo-ichi Nabeshima

    (National Institute of Neuroscience, NCNP
    Core Research for Evolutional Science & Technology (CREST), JRDC and
    Institute for Molecular and Cellular Biology, Osaka University)

Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the β-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

Suggested Citation

  • Makoto Kuro-o & Yutaka Matsumura & Hiroki Aizawa & Hiroshi Kawaguchi & Tatsuo Suga & Toshihiro Utsugi & Yoshio Ohyama & Masahiko Kurabayashi & Tadashi Kaname & Eisuke Kume & Hitoshi Iwasaki & Akihiro , 1997. "Mutation of the mouse klotho gene leads to a syndrome resembling ageing," Nature, Nature, vol. 390(6655), pages 45-51, November.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6655:d:10.1038_36285
    DOI: 10.1038/36285
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    Cited by:

    1. Hirokazu Sakan & Kimihiko Nakatani & Osamu Asai & Akihiro Imura & Tomohiro Tanaka & Shuhei Yoshimoto & Noriyuki Iwamoto & Norio Kurumatani & Masayuki Iwano & Yo-ichi Nabeshima & Noboru Konishi & Yoshi, 2014. "Reduced Renal α-Klotho Expression in CKD Patients and Its Effect on Renal Phosphate Handling and Vitamin D Metabolism," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.
    2. Javier Botey-Bataller & Hedwig D. Vrijmoeth & Jeanine Ursinus & Bart-Jan Kullberg & Cees C. Wijngaard & Hadewych Hofstede & Ahmed Alaswad & Manoj K. Gupta & Lennart M. Roesner & Jochen Huehn & Thomas , 2024. "A comprehensive genetic map of cytokine responses in Lyme borreliosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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