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Of fingers, toes and penises

Author

Listed:
  • Takashi Kondo

    (University of Geneva
    University of Michigan Medical School)

  • József Zákány

    (University of Geneva
    University of Michigan Medical School)

  • Jeffrey W. Innis

    (University of Geneva
    University of Michigan Medical School)

  • Denis Duboule

    (University of Geneva
    University of Michigan Medical School)

Abstract

Vertebrate Hox genes are essential for limb development. The posterior-most Hoxd and Hoxa genes are required for growth and patterning of digits and are also strongly expressed in the genital bud, which gives rise to the urogenital system, including the penis. Here, we show that removal of posterior Hox gene function results in a concomitant loss of digits and genital bud-derivatives, illustrating that similar developmental mechanisms are at work in these different buds.

Suggested Citation

  • Takashi Kondo & József Zákány & Jeffrey W. Innis & Denis Duboule, 1997. "Of fingers, toes and penises," Nature, Nature, vol. 390(6655), pages 29-29, November.
    • Handle: RePEc:nat:nature:v:390:y:1997:i:6655:d:10.1038_36234
    DOI: 10.1038/36234
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    Cited by:

    1. Anastasiia Lozovska & Artemis G. Korovesi & André Dias & Alexandre Lopes & Donald A. Fowler & Gabriel G. Martins & Ana Nóvoa & Moisés Mallo, 2024. "Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. John M Coates & Lionel Page, 2009. "A Note on Trader Sharpe Ratios," PLOS ONE, Public Library of Science, vol. 4(11), pages 1-5, November.
    3. Ellen Garbarino & Robert Slonim & Justin Sydnor, 2011. "Digit ratios (2D:4D) as predictors of risky decision making for both sexes," Journal of Risk and Uncertainty, Springer, vol. 42(1), pages 1-26, February.

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