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Daughters against dpp modulates dpp organizing activity in Drosophila wing development

Author

Listed:
  • Kazuhide Tsuneizumi

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo)

  • Takuya Nakayama

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo
    Oregon Health Sciences University)

  • Yuko Kamoshida

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo)

  • Thomas B. Kornberg

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo
    University of California)

  • Jan L. Christian

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo
    Oregon Health Sciences University)

  • Tetsuya Tabata

    (Institute of Molecular and Cellular Biosciences, The University of Tokyo)

Abstract

The family of TGF-β signalling molecules play inductive roles in various developmental contexts1. One member of this family, Drosophila Decapentaplegic (Dpp)2 serves as a morphogen that patterns both the embryo3,1 and adult4,5. We have now isolated a gene, Daughters against dpp ( Dad), whose transcription is induced by Dpp. Dad shares weak homology with Drosophila Mad (Mothers against dpp)6, a protein required for transduction of Dpp signals. In contrast to Mad or the activated Dpp receptor, whose overexpression hyperactivates the Dpp signalling pathway, overexpression of Dad blocks Dpp activity. Expression of Dad together with either Mad or the activated receptor rescues phenotypic defects induced by each protein alone. Dad can also antagonize the activity of a vertebrate homologue of Dpp, bone morphogenetic protein (BMP-4; ref. 7), as evidenced by induction of dorsal or neural fate following overexpression in Xenopus embryos. We conclude that the pattern-organizing mechanism governed by Dpp involves a negative-feedback circuit in which Dpp induces expression of its own antagonist, Dad. This feedback loop appears to be conserved in vertebrate development.

Suggested Citation

  • Kazuhide Tsuneizumi & Takuya Nakayama & Yuko Kamoshida & Thomas B. Kornberg & Jan L. Christian & Tetsuya Tabata, 1997. "Daughters against dpp modulates dpp organizing activity in Drosophila wing development," Nature, Nature, vol. 389(6651), pages 627-631, October.
    • Handle: RePEc:nat:nature:v:389:y:1997:i:6651:d:10.1038_39362
    DOI: 10.1038/39362
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    Cited by:

    1. Fisun Hamaratoglu & Aitana Morton de Lachapelle & George Pyrowolakis & Sven Bergmann & Markus Affolter, 2011. "Dpp Signaling Activity Requires Pentagone to Scale with Tissue Size in the Growing Drosophila Wing Imaginal Disc," PLOS Biology, Public Library of Science, vol. 9(10), pages 1-17, October.
    2. Esteban J Beckwith & E Axel Gorostiza & Jimena Berni & Carolina Rezával & Agustín Pérez-Santángelo & Alejandro D Nadra & María Fernanda Ceriani, 2013. "Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway," PLOS Biology, Public Library of Science, vol. 11(12), pages 1-15, December.

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