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Feedback from inhibitory SMADs

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  • Malcolm Whitman

    (Harvard Medical School)

Abstract

Many biological processes involve signalling through the transforming growth factor-b (TGF-β) superfamily of proteins. In some pathways, TGF-b signals are mediated through the SMAD family of signal transducers. Smads 1, 2, 3 and 5 are activated when members of the TGF-b family bind their receptors, leading to association with Smad4 and a transcriptional response. Three groups now independently show that two new SMADs (Smads 6 and 7) and a Drosophila homologue inhibit this signalling process.

Suggested Citation

  • Malcolm Whitman, 1997. "Feedback from inhibitory SMADs," Nature, Nature, vol. 389(6651), pages 549-551, October.
    • Handle: RePEc:nat:nature:v:389:y:1997:i:6651:d:10.1038_39202
    DOI: 10.1038/39202
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