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Anaesthetics set their sites on ion channels

Author

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  • N. P. Franks

    (the Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine)

  • W. R. Lieb

    (the Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine)

Abstract

The effects of alcohol and general anaesthetics are obvious to everybody, but where in the brain — and how — do these agents act? By making hybrid GABAA- and glycine-receptor channels, one group has now identified two amino-acid residues that seem to be crucial for this process. Amino-acid substitutions at these positions remove the effects of anaesthetics, but it's not yet possible to tell whether these amino acids represent a direct binding site, or whether they are involved more indirectly.

Suggested Citation

  • N. P. Franks & W. R. Lieb, 1997. "Anaesthetics set their sites on ion channels," Nature, Nature, vol. 389(6649), pages 334-335, September.
    • Handle: RePEc:nat:nature:v:389:y:1997:i:6649:d:10.1038_38614
    DOI: 10.1038/38614
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