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Phospholipase C isozymes selectively couple to specific neurotransmitter receptors

Author

Listed:
  • Daesoo Kim
  • Ki Sun Jun
  • Seong Beom Lee

    (Pohang University of Science and Technology, San-31)

  • Nae-Gyu Kang

    (Pohang University of Science and Technology, San-31)

  • Do Sik Min

    (Pohang University of Science and Technology, San-31)

  • Young-Hoon Kim

    (Institute of Neuroscience, Inje University, 633-165)

  • Sung Ho Ryu

    (Pohang University of Science and Technology, San-31)

  • Pann-Ghill Suh

    (Pohang University of Science and Technology, San-31)

  • Hee-Sup Shin

    (Pohang University of Science and Technology, San-31)

Abstract

A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-β (PLC-β) coupled with guanine-nucleotide-binding G proteins1. There are four isoenzymes of PLC-β, β1–β4, but their functions in vivo are not known. Here we investigate the role of PLC-β1 and PLC-β4 in the brain by generating null mutations in mice: we found that PLCβ1−/− mice developed epilepsy and PLCβ4−/− mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-β1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling predominantly to the muscarinic acetylcholine receptor, whereas PLC-β4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-β isoenzymes are used to generate different functions in the brain.

Suggested Citation

  • Daesoo Kim & Ki Sun Jun & Seong Beom Lee & Nae-Gyu Kang & Do Sik Min & Young-Hoon Kim & Sung Ho Ryu & Pann-Ghill Suh & Hee-Sup Shin, 1997. "Phospholipase C isozymes selectively couple to specific neurotransmitter receptors," Nature, Nature, vol. 389(6648), pages 290-293, September.
    • Handle: RePEc:nat:nature:v:389:y:1997:i:6648:d:10.1038_38508
    DOI: 10.1038/38508
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