IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v389y1997i6647d10.1038_38160.html
   My bibliography  Save this article

Caffeine alters plasma adenosine levels

Author

Listed:
  • Lydia A. Conlay

    (Massachusetts General Hospital and Harvard Medical School
    Laboratory of Neuroendocrine Regulation
    Massachusetts Institute of Technology)

  • Jeffrey A. Conant

    (Massachusetts General Hospital and Harvard Medical School
    Laboratory of Neuroendocrine Regulation
    Massachusetts Institute of Technology)

  • Fred deBros

    (Massachusetts General Hospital and Harvard Medical School)

  • Richard Wurtman

    (Laboratory of Neuroendocrine Regulation
    Massachusetts Institute of Technology)

Abstract

Since the delights of tea were discovered by Emperor Shen Nung in 2737 BC, methylxanthines have been common in the human diet. Today, the methylxanthine caffeineis the most commonly consumed drug in the world1, with actions mediated primarily by adenosine receptor blockade2. We now report that caffeine increases plasma adenosine concentration in a manner that is dose-related, saturable, and mimicked by peripheral adenosine receptor blockade. Opposite effects are seen after caffeine withdrawal, indicative of a receptor-mediated effect.

Suggested Citation

  • Lydia A. Conlay & Jeffrey A. Conant & Fred deBros & Richard Wurtman, 1997. "Caffeine alters plasma adenosine levels," Nature, Nature, vol. 389(6647), pages 136-136, September.
    • Handle: RePEc:nat:nature:v:389:y:1997:i:6647:d:10.1038_38160
    DOI: 10.1038/38160
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/38160
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/38160?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Julia Brunmair & Mathias Gotsmy & Laura Niederstaetter & Benjamin Neuditschko & Andrea Bileck & Astrid Slany & Max Lennart Feuerstein & Clemens Langbauer & Lukas Janker & Jürgen Zanghellini & Samuel M, 2021. "Finger sweat analysis enables short interval metabolic biomonitoring in humans," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:389:y:1997:i:6647:d:10.1038_38160. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.