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Guides to 95 new angles

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  • B. Edward H. Maden

    (School of Biological Sciences, Life Sciences Building, University of Liverpool)

Abstract

Pseudouridine (y) is a modified form of uridine — the base that occurs only in RNA. But how is it formed? Four new papers now show that formation of y relies on a group of small nucleolar RNAs (snoRNAs), which hydridize with the target RNA sequence, but leave an unpaired window that allows the y synthase to gain access. Surprisingly, this is the same method that is used for ribose methylation of RNA.

Suggested Citation

  • B. Edward H. Maden, 1997. "Guides to 95 new angles," Nature, Nature, vol. 389(6647), pages 129-130, September.
  • Handle: RePEc:nat:nature:v:389:y:1997:i:6647:d:10.1038_38134
    DOI: 10.1038/38134
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