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Reversing the kinesin ratchet — a diverting tail

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  • R. A. Cross

    (Molecular Motors Group, Marie Curie Research Institute)

Abstract

Motor proteins such as kinesin help to haul cellular cargo along microtubules, and they are mechanically programmed to move in one direction only -- towards either the rapidly growing plus ends, or the static minus ends. But what determines the direction of movement? To address this question, a chimaera has been created in which the head of a minus-end kinesin is attached to the tail ofa plus-end kinesin. And the chimaera moves in the opposite direction to the minus-end heads.

Suggested Citation

  • R. A. Cross, 1997. "Reversing the kinesin ratchet — a diverting tail," Nature, Nature, vol. 389(6646), pages 15-16, September.
    • Handle: RePEc:nat:nature:v:389:y:1997:i:6646:d:10.1038_37864
    DOI: 10.1038/37864
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