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Endogenous proviruses as “mementos”?

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  • Jonathan Stoye

    (National Institute for Medical Research)

Abstract

Stoye replies — On the basis of analogies between P elements and retroviruses, Langley and Charlesworth suggest that one potential risk associated with xenotransplantation is a form of insertional mutagenesis resulting from germline integrations by retroviruses derived from endogenous proviruses in the engrafted organs. I agree that these elements are potentially hazardous, but I am not convinced that the threat posed by this form of genomic bombardmentis great enough to figure significantly in risk-benefit analysis of xenotransplantation. Rather, the much greater risk is that posed by these elements acting as infectious agents of disease.

Suggested Citation

  • Jonathan Stoye, 1997. "Endogenous proviruses as “mementos”?," Nature, Nature, vol. 388(6645), pages 840-840, August.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6645:d:10.1038_42172
    DOI: 10.1038/42172
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