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Silencing and DNA repair connect

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  • Stephen P. Jackson

    (University of Cambridge)

Abstract

In defined regions of the genome of eukaryotic organisms DNA is packaged into a form of chromatin known as heterochromatin, the main feature of which is that the DNA generally cannot be transcribed. In the yeastSaccharomyces cerevisiae, the so-called Sir proteins are associated with this transcriptional silencing, and it now emerges that they are also involved in repairing double-strand breaks in DNA induced by ionizing radiation. This is an unexpected and potentially fruitful connection.

Suggested Citation

  • Stephen P. Jackson, 1997. "Silencing and DNA repair connect," Nature, Nature, vol. 388(6645), pages 829-830, August.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6645:d:10.1038_42136
    DOI: 10.1038/42136
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