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Calcium cages, acid baths and recycling receptors

Author

Listed:
  • Michael S. Brown

    (University of Texas Southwestern Medical Center)

  • Joachim Herz

    (University of Texas Southwestern Medical Center)

  • Joseph L. Goldstein

    (University of Texas Southwestern Medical Center)

Abstract

The low-density lipoprotein receptor (LDLR) removes cholesterol-carrying lipoproteins from the blood, and mutations in this protein lead to familial hypercholesterolaemia -- a condition that leads to high cholesterol levels and heart attacks at an early age. We're now a step closer to knowing why these mutations are so damaging thanks to a study of one region of the receptor, mutations in which destabilize the whole protein.

Suggested Citation

  • Michael S. Brown & Joachim Herz & Joseph L. Goldstein, 1997. "Calcium cages, acid baths and recycling receptors," Nature, Nature, vol. 388(6643), pages 629-630, August.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6643:d:10.1038_41672
    DOI: 10.1038/41672
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