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The complete genome sequence of the gastric pathogen Helicobacter pylori

Author

Listed:
  • Jean-F. Tomb

    (The Institute for Genomic Research)

  • Owen White

    (The Institute for Genomic Research)

  • Anthony R. Kerlavage

    (The Institute for Genomic Research)

  • Rebecca A. Clayton

    (The Institute for Genomic Research)

  • Granger G. Sutton

    (The Institute for Genomic Research)

  • Robert D. Fleischmann

    (The Institute for Genomic Research)

  • Karen A. Ketchum

    (The Institute for Genomic Research)

  • Hans Peter Klenk

    (The Institute for Genomic Research)

  • Steven Gill

    (The Institute for Genomic Research)

  • Brian A. Dougherty

    (The Institute for Genomic Research)

  • Karen Nelson

    (The Institute for Genomic Research)

  • John Quackenbush

    (The Institute for Genomic Research)

  • Lixin Zhou

    (The Institute for Genomic Research)

  • Ewen F. Kirkness

    (The Institute for Genomic Research)

  • Scott Peterson

    (The Institute for Genomic Research)

  • Brendan Loftus

    (The Institute for Genomic Research)

  • Delwood Richardson

    (The Institute for Genomic Research)

  • Robert Dodson

    (The Institute for Genomic Research)

  • Hanif G. Khalak

    (The Institute for Genomic Research)

  • Anna Glodek

    (The Institute for Genomic Research)

  • Keith McKenney

    (The Institute for Genomic Research)

  • Lisa M. Fitzegerald

    (The Institute for Genomic Research)

  • Norman Lee

    (The Institute for Genomic Research)

  • Mark D. Adams

    (The Institute for Genomic Research)

  • Erin K. Hickey

    (The Institute for Genomic Research)

  • Douglas E. Berg

    (School of Medicine, Washington University St Louis)

  • Jeanine D. Gocayne

    (The Institute for Genomic Research)

  • Teresa R. Utterback

    (The Institute for Genomic Research)

  • Jeremy D. Peterson

    (The Institute for Genomic Research)

  • Jenny M. Kelley

    (The Institute for Genomic Research)

  • Matthew D. Cotton

    (The Institute for Genomic Research)

  • Janice M. Weidman

    (The Institute for Genomic Research)

  • Claire Fujii

    (The Institute for Genomic Research)

  • Cheryl Bowman

    (The Institute for Genomic Research)

  • Larry Watthey

    (The Institute for Genomic Research)

  • Erik Wallin

    (Arrhenius Laboratory, Stockholm University)

  • William S. Hayes

    (School of Biology)

  • Mark Borodovsky

    (School of Biology)

  • Peter D. Karp

    (SRI International, Artificial Intelligence Center)

  • Hamilton O. Smith

    (School of Medicine, Johns Hopkins University)

  • Claire M. Fraser

    (The Institute for Genomic Research)

  • J. Craig Venter

    (The Institute for Genomic Research)

Abstract

Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host–pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.

Suggested Citation

  • Jean-F. Tomb & Owen White & Anthony R. Kerlavage & Rebecca A. Clayton & Granger G. Sutton & Robert D. Fleischmann & Karen A. Ketchum & Hans Peter Klenk & Steven Gill & Brian A. Dougherty & Karen Nelso, 1997. "The complete genome sequence of the gastric pathogen Helicobacter pylori," Nature, Nature, vol. 388(6642), pages 539-547, August.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6642:d:10.1038_41483
    DOI: 10.1038/41483
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