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From RAGs to stitches

Author

Listed:
  • David T. Weaver

    (Center for Blood Research)

  • Fredrick W. Alt

    (Center for Blood Research
    Howard Hughes Medical Institute, The Childrens Hospital and Center for Blood Research)

Abstract

V(D)Jrecombination is used by lymphocytes to assemble the variable regions of antigen receptors. It involves the formation of a DNA double-strand break, followed by rejoining of the blunt DNA ends. Studies of the breakage and rejoining reactions will be facilitated by the development of a new, cell-free system in mammalian cells, and the identification of a hitherto undiscovered component of this system in yeast.

Suggested Citation

  • David T. Weaver & Fredrick W. Alt, 1997. "From RAGs to stitches," Nature, Nature, vol. 388(6641), pages 428-429, July.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6641:d:10.1038_41225
    DOI: 10.1038/41225
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