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The difference with prokaryotes

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  • Mary-Jane Gething

    (University of Melbourne)

Abstract

In prokaryotes, the polypeptide chains in which proteins are synthesized only tend to fold into their final, operational form when the chain is complete. In eukaryotes, by contrast, individual domains of a single protein can fold sequentially and independently. This striking finding can help to resolve the puzzle of why prokaryotes tend to rely much more heavily on chaperonin- assisted protein folding than do eukaryotes, but the molecular mechanisms underlying the different treatment of nascent polypeptide chains remain to be defined.

Suggested Citation

  • Mary-Jane Gething, 1997. "The difference with prokaryotes," Nature, Nature, vol. 388(6640), pages 329-331, July.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6640:d:10.1038_40979
    DOI: 10.1038/40979
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