IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v388y1997i6639d10.1038_40805.html
   My bibliography  Save this article

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

Author

Listed:
  • Susan Tsunoda

    (University of California at San Diego)

  • Jimena Sierralta

    (University of California at San Diego)

  • Yumei Sun

    (University of California at San Diego)

  • Ruth Bodner

    (University of California at San Diego)

  • Emiko Suzuki

    (*The Insitute of Medical Science, The University of Tokyo)

  • Ann Becker

    (University of California at San Diego)

  • Michael Socolich

    (University of California at San Diego)

  • Charles S. Zuker

    (University of California at San Diego)

Abstract

How are signalling molecules organized into different pathways within the same cell? In Drosophila, the inaD gene encodes a protein consisting of five PDZ domains which serves as a scaffold to assemble different components of the phototransduction cascade, including the principal light-activated ion channels, the effector phospholipase C-β and protein kinase C. Null inaD mutants have a dramatically reorganized subcellular distribution of signalling molecules, and a total loss of transduction complexes. Also, mutants defective in a single PDZ domain produce signalling complexes that lack the target protein and display corresponding defects in their physiology. A picture emerges of a highly organized unit of signalling, a ‘transducisome’, with PDZ domains functioning as key elements in the organization of transduction complexes in vivo.

Suggested Citation

  • Susan Tsunoda & Jimena Sierralta & Yumei Sun & Ruth Bodner & Emiko Suzuki & Ann Becker & Michael Socolich & Charles S. Zuker, 1997. "A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade," Nature, Nature, vol. 388(6639), pages 243-249, July.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6639:d:10.1038_40805
    DOI: 10.1038/40805
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/40805
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/40805?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Khaled Daqrouq & Rami Alhmouz & Ahmed Balamesh & Adnan Memic, 2015. "Application of Wavelet Transform for PDZ Domain Classification," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-16, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:388:y:1997:i:6639:d:10.1038_40805. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.