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A new SIV co-receptor, STRL33

Author

Listed:
  • Ghalib Alkhatib

    (*Laboratory of Viral Diseases, NIAID, National Institutes of Health)

  • Fang Liao

    (†Laboratory of Clinical Investigation, NIAID, National Institutes of Health)

  • Edward A. Berger

    (*Laboratory of Viral Diseases, NIAID, National Institutes of Health)

  • Joshua M. Farber

    (†Laboratory of Clinical Investigation, NIAID, National Institutes of Health)

  • Keith W. C. Peden

    (Laboratory of Retrovirus Research, CBER, Food and Drug Administration)

Abstract

The identification last year of chemokine receptors as fusion co-factors for HIV-11,2,3,4,5,6 has contributed significantly towards understanding HIV transmission and AIDS pathogenesis (see ref. 7 for a review). Because the experimental infection of rhesus macaques with simian immunodeficiency virus (SIV) and the resulting development of an AIDS-like illness is the best animal model for HIV disease in humans8, identifying SIV co-receptors analogous to those used by HIV has obvious importance. We now report that STRL33, a chemokine receptor-like orphan receptor expressed in activated human lymphocytes and acting as a fusion co-factor with envelope glycoproteins (Envs) from HIV-1 strains of diverse tropisms9, is a co-receptor for SIV.

Suggested Citation

  • Ghalib Alkhatib & Fang Liao & Edward A. Berger & Joshua M. Farber & Keith W. C. Peden, 1997. "A new SIV co-receptor, STRL33," Nature, Nature, vol. 388(6639), pages 238-238, July.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6639:d:10.1038_40789
    DOI: 10.1038/40789
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