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Lifetime of plasma cells in the bone marrow

Author

Listed:
  • Rudolf A. Manz

    (Institute for Genetics, University of Cologne
    Deutsches Rheumaforschungszentrum Berlin)

  • Andreas Thiel

    (Institute for Genetics, University of Cologne
    Deutsches Rheumaforschungszentrum Berlin)

  • Andreas Radbruch

    (Institute for Genetics, University of Cologne
    Deutsches Rheumaforschungszentrum Berlin)

Abstract

Immune protection is based on long-lived memory cells and effector cells, which are either cytotoxic or secrete antibodies. The lifespan of these effector cells has not so far been determined. Here we show that antibody-secreting plasma cells from bone marrow are as long-lived as memory B cells.

Suggested Citation

  • Rudolf A. Manz & Andreas Thiel & Andreas Radbruch, 1997. "Lifetime of plasma cells in the bone marrow," Nature, Nature, vol. 388(6638), pages 133-134, July.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6638:d:10.1038_40540
    DOI: 10.1038/40540
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    Cited by:

    1. Marta Ferreira-Gomes & Yidan Chen & Pawel Durek & Hector Rincon-Arevalo & Frederik Heinrich & Laura Bauer & Franziska Szelinski & Gabriela Maria Guerra & Ana-Luisa Stefanski & Antonia Niedobitek & Ann, 2024. "Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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