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Inhibition of ICE slows ALS in mice

Author

Listed:
  • Robert M. Friedlander

    (Neurosurgical Service, Massachusetts General Hospital, Harvard Medical School)

  • Robert H. Brown

    (Day Neuromuscular Research Laboratory, Massachusetts General Hospital)

  • Valeria Gagliardini

    (Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School)

  • Joy Wang

    (Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School)

  • Junying Yuan

    (Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School)

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive age-dependent disease involving degeneration of motor neurons in the brain, brainstem and spinal cord. ALS is universally fatal, with the median survival of patients being five years from diagnosis. In a transgenic mouse model of ALS, we now show that a dominant negative inhibitor of a cell-death gene, the interleukin-1β-converting enzyme (ICE), significantly slows the symptomatic progression of ALS.

Suggested Citation

  • Robert M. Friedlander & Robert H. Brown & Valeria Gagliardini & Joy Wang & Junying Yuan, 1997. "Inhibition of ICE slows ALS in mice," Nature, Nature, vol. 388(6637), pages 31-31, July.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6637:d:10.1038_40299
    DOI: 10.1038/40299
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