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Role of mutator alleles in adaptive evolution

Author

Listed:
  • F. Taddei

    (*Laboratoire de Mutagenèse, Institut J. Monod, CNRS Université Paris 7
    #Ecole Nationale du Génie Rural, des Eaux et des Forêts)

  • M. Radman

    (*Laboratoire de Mutagenèse, Institut J. Monod, CNRS Université Paris 7)

  • J. Maynard-Smith

    (†University of Sussex, Microbial Genetics Group, School of Biological Sciences)

  • B. Toupance

    (‡Université de Paris-Sud CNRS, Laboratoire Évolution et Systématique)

  • P. H. Gouyon

    (‡Université de Paris-Sud CNRS, Laboratoire Évolution et Systématique)

  • B. Godelle

    (‡Université de Paris-Sud CNRS, Laboratoire Évolution et Systématique
    §Institut National Agronomique Paris-Grignon)

Abstract

Because most newly arising mutations are neutral or deleterious, it has been argued1,2,3 that the mutation rate has evolved to be as low as possible, limited only by the cost of error-avoidance and error-correction mechanisms. But up to one per cent of natural bacterial isolates are ‘mutator’ clones that have high mutation rates4,5,6. We consider here whether high mutation rates might playan important role in adaptive evolution. Models of large, asexual, clonal populations adapting to a new environment show that strong mutator genes (such as those that increase mutation rates by 1,000-fold) can accelerate adaptation, even if the mutator gene remains at a very low frequency (for example, 10−5). Less potent mutators (10 to 100-fold increase) can become fixed in a fraction of finite populations. The parameters of the model have been set to values typical for Escherichia coli cultures, which behave in a manner similar to the model in long-term adaptation experiments7.

Suggested Citation

  • F. Taddei & M. Radman & J. Maynard-Smith & B. Toupance & P. H. Gouyon & B. Godelle, 1997. "Role of mutator alleles in adaptive evolution," Nature, Nature, vol. 387(6634), pages 700-702, June.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6634:d:10.1038_42696
    DOI: 10.1038/42696
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    Cited by:

    1. Arturo Marín & Héctor Tejero & Juan Carlos Nuño & Francisco Montero, 2013. "The Advantage of Arriving First: Characteristic Times in Finite Size Populations of Error-Prone Replicators," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-12, December.
    2. Muirhead, Stephen & Pymar, Richard, 2016. "Localisation in the Bouchaud–Anderson model," Stochastic Processes and their Applications, Elsevier, vol. 126(11), pages 3402-3462.
    3. Startek, Michał & Le Rouzic, Arnaud & Capy, Pierre & Grzebelus, Dariusz & Gambin, Anna, 2013. "Genomic parasites or symbionts? Modeling the effects of environmental pressure on transposition activity in asexual populations," Theoretical Population Biology, Elsevier, vol. 90(C), pages 145-151.
    4. Greenspoon, Philip B. & Mideo, Nicole, 2017. "Evolutionary rescue of a parasite population by mutation rate evolution," Theoretical Population Biology, Elsevier, vol. 117(C), pages 64-75.

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