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The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

Author

Listed:
  • Joseph Torchia

    (*Howard Hughes Medical Institute, University of California)

  • David W. Rose

    (University of California)

  • Juan Inostroza

    (*Howard Hughes Medical Institute, University of California)

  • Yasutomi Kamei

    (*Howard Hughes Medical Institute, University of California)

  • Stefan Westin

    (Cellular and Molecular Medicine, University of California)

  • Christopher K. Glass

    (Cellular and Molecular Medicine, University of California)

  • Michael G. Rosenfeld

    (*Howard Hughes Medical Institute, University of California)

Abstract

The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways.

Suggested Citation

  • Joseph Torchia & David W. Rose & Juan Inostroza & Yasutomi Kamei & Stefan Westin & Christopher K. Glass & Michael G. Rosenfeld, 1997. "The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function," Nature, Nature, vol. 387(6634), pages 677-684, June.
    • Handle: RePEc:nat:nature:v:387:y:1997:i:6634:d:10.1038_42652
    DOI: 10.1038/42652
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